The extensive polymorphism of KIR genes
D Middleton, F Gonzelez - Immunology, 2010 - Wiley Online Library
The functions of human natural killer (NK) cells are controlled by diverse families of antigen
receptors. Prominent among these are the killer cell immunoglobulin‐like receptors (KIR), a …
receptors. Prominent among these are the killer cell immunoglobulin‐like receptors (KIR), a …
NK cell therapy for hematologic malignancies
RS Mehta, B Randolph, M Daher, K Rezvani - International journal of …, 2018 - Springer
Natural killer (NK) cells are part of the innate immune system and represent the first line of
defense against infections and tumors. In contrast to T cells, NK cells do not require prior …
defense against infections and tumors. In contrast to T cells, NK cells do not require prior …
CMV drives clonal expansion of NKG2C+ NK cells expressing self‐specific KIRs in chronic hepatitis patients
Natural killer (NK) cells are affected by infection with human cytomegalovirus (HCMV)
manifested by increased expression of the HLA‐E binding activating receptor NKG2C. We …
manifested by increased expression of the HLA‐E binding activating receptor NKG2C. We …
MHC class I–specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response
M Yawata, N Yawata, M Draghi… - Blood, The Journal …, 2008 - ashpublications.org
Variegated expression of 6 inhibitory HLA class I–specific receptors on primary NK cells was
studied using high-dimension flow cytometry in 58 humans to understand the structure and …
studied using high-dimension flow cytometry in 58 humans to understand the structure and …
Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity
CG Brunstein, JE Wagner, DJ Weisdorf… - Blood, The Journal …, 2009 - ashpublications.org
We examined the clinical impact of killer-immunoglobulin receptor-ligand (KIR-L) mismatch
in 257 recipients of single (n= 91) or double (n= 166) unit umbilical cord blood (UCB) grafts …
in 257 recipients of single (n= 91) or double (n= 166) unit umbilical cord blood (UCB) grafts …
Natural killer cell allorecognition of missing self in allogeneic hematopoietic transplantation: a tool for immunotherapy of leukemia
A Velardi, L Ruggeri, A Mancusi, F Aversa… - Current opinion in …, 2009 - Elsevier
Donor-versus-recipient natural killer (NK) cell alloreactivity has been established as a key
therapeutic element in HLA haplotype mismatched hematopoietic transplants in adult AML …
therapeutic element in HLA haplotype mismatched hematopoietic transplants in adult AML …
KIR and HLA Genotypes Are Associated with Disease Progression and Survival following Autologous Hematopoietic Stem Cell Transplantation for High-Risk …
JM Venstrom, J Zheng, N Noor, KE Danis, AW Yeh… - Clinical Cancer …, 2009 - AACR
Purpose: NK cells exhibit cytotoxicity against neuroblastoma. Gene polymorphisms
governing NK cell function, therefore, may influence prognosis. Two highly polymorphic …
governing NK cell function, therefore, may influence prognosis. Two highly polymorphic …
Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell–depleted allogeneic …
J Yu, JM Venstrom, XR Liu, J Pring… - Blood, The Journal …, 2009 - ashpublications.org
Alloreactive natural killer (NK) cells are an important influence on hematopoietic stem cell
transplantation (HSCT) outcome. In HLA-mismatched HSCT, alloreactivity occurs when …
transplantation (HSCT) outcome. In HLA-mismatched HSCT, alloreactivity occurs when …
Natural killer cells expressing the KIR2DS1-activating receptor efficiently kill T-cell blasts and dendritic cells: implications in haploidentical HSCT
In allogeneic HSCT, NK-cell alloreactivity is determined by the presence in the donor of NK
cells expressing inhibitory killer cell Ig-like receptors (KIRs) that recognize HLA class I …
cells expressing inhibitory killer cell Ig-like receptors (KIRs) that recognize HLA class I …
KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression
S Andersson, C Fauriat, JA Malmberg… - Blood, The Journal …, 2009 - ashpublications.org
Inhibitory killer cell immunoglobulin-like receptors (KIRs) preserve tolerance to self and
shape the functional response of human natural killer (NK) cells. Here, we have evaluated …
shape the functional response of human natural killer (NK) cells. Here, we have evaluated …