The latest in animal models of pulmonary hypertension and right ventricular failure
Pulmonary hypertension (PH) describes heterogeneous population of patients with a mean
pulmonary arterial pressure> 20 mm Hg. Rarely, PH presents as a primary disorder but is …
pulmonary arterial pressure> 20 mm Hg. Rarely, PH presents as a primary disorder but is …
[HTML][HTML] Sex, gender, and sex hormones in pulmonary hypertension and right ventricular failure
J Hester, C Ventetuolo, T Lahm - Comprehensive Physiology, 2019 - ncbi.nlm.nih.gov
Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …
[HTML][HTML] Endothelial to mesenchymal transition contributes to endothelial dysfunction in pulmonary arterial hypertension
RB Good, AJ Gilbane, SL Trinder, CP Denton… - The American journal of …, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung
endothelial cell dysfunction and vascular remodeling. Normally, the endothelium forms an …
endothelial cell dysfunction and vascular remodeling. Normally, the endothelium forms an …
Matrix remodeling promotes pulmonary hypertension through feedback mechanoactivation of the YAP/TAZ-miR-130/301 circuit
Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins.
We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and …
We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and …
Prolyl-4 hydroxylase 2 (PHD2) deficiency in endothelial cells and hematopoietic cells induces obliterative vascular remodeling and severe pulmonary arterial …
Background—Vascular occlusion and complex plexiform lesions are hallmarks of the
pathology of severe pulmonary arterial hypertension (PAH) in patients. However, the …
pathology of severe pulmonary arterial hypertension (PAH) in patients. However, the …
Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension
J Rodor, SH Chen, JP Scanlon… - Cardiovascular …, 2022 - academic.oup.com
Aims Endothelial cell (EC) dysfunction drives the initiation and pathogenesis of pulmonary
arterial hypertension (PAH). We aimed to characterize EC dynamics in PAH at single-cell …
arterial hypertension (PAH). We aimed to characterize EC dynamics in PAH at single-cell …
Vascular remodeling in pulmonary hypertension
LA Shimoda, SS Laurie - Journal of molecular medicine, 2013 - Springer
Pulmonary hypertension is a complex, progressive condition arising from a variety of genetic
and pathogenic causes. Patients present with a spectrum of histologic and …
and pathogenic causes. Patients present with a spectrum of histologic and …
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension
Development of the vascular disease pulmonary hypertension (PH) involves disparate
molecular pathways that span multiple cell types. MicroRNAs (miRNAs) may coordinately …
molecular pathways that span multiple cell types. MicroRNAs (miRNAs) may coordinately …
MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach
VN Parikh, RC Jin, S Rabello, N Gulbahce, K White… - Circulation, 2012 - Am Heart Assoc
Background—Pulmonary hypertension (PH) is driven by diverse pathogenic etiologies.
Owing to their pleiotropic actions, microRNA molecules are potential candidates for …
Owing to their pleiotropic actions, microRNA molecules are potential candidates for …
A comprehensive review: the evolution of animal models in pulmonary hypertension research; are we there yet?
Pulmonary hypertension (PH) is a disorder that develops as a result of remodeling of the
pulmonary vasculature and is characterized by narrowing/obliteration of small pulmonary …
pulmonary vasculature and is characterized by narrowing/obliteration of small pulmonary …