The state of our understanding of the pathophysiology and optimal treatment of depression: glass half full or half empty?
CB Nemeroff - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
Major depressive disorder is a remarkably common and often severe psychiatric disorder
associated with high levels of morbidity and mortality. Patients with major depression are …
associated with high levels of morbidity and mortality. Patients with major depression are …
Functional connectomics in depression: insights into therapies
Depression is a common mental disorder characterized by heterogeneous cognitive and
behavioral symptoms. The emerging research paradigm of functional connectomics has …
behavioral symptoms. The emerging research paradigm of functional connectomics has …
[HTML][HTML] The critical relationship between anxiety and depression
NH Kalin - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
Anxiety and depressive disorders are among the most common psychiatric illnesses; they
are highly comorbid with each other, and together they are considered to belong to the …
are highly comorbid with each other, and together they are considered to belong to the …
[HTML][HTML] Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study
Psychiatric sequelae substantially contribute to the post-acute burden of disease associated
with COVID-19, persisting months after clearance of the virus. Brain imaging shows white …
with COVID-19, persisting months after clearance of the virus. Brain imaging shows white …
Heart rate and skin conductance associations with physical aggression, psychopathy, antisocial personality disorder and conduct disorder: An updated meta-analysis
PC De Looff, LJM Cornet, CH De Kogel… - Neuroscience & …, 2022 - Elsevier
The associations between physiological measures (ie, heart rate and skin conductance) of
autonomic nervous system (ANS) activity and severe antisocial spectrum behavior (AB) …
autonomic nervous system (ANS) activity and severe antisocial spectrum behavior (AB) …
[HTML][HTML] A cultural-ecosocial systems view for psychiatry
A Gómez-Carrillo, LJ Kirmayer - Frontiers in Psychiatry, 2023 - frontiersin.org
While contemporary psychiatry seeks the mechanisms of mental disorders in neurobiology,
mental health problems clearly depend on developmental processes of learning and …
mental health problems clearly depend on developmental processes of learning and …
Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression
Major depressive disorder (MDD) is a devastating mental disorder that affects up to 17% of
the population worldwide. Although brain-wide network-level abnormalities in MDD patients …
the population worldwide. Although brain-wide network-level abnormalities in MDD patients …
[HTML][HTML] Vitamin D in depression: A potential bioactive agent to reduce suicide and suicide attempt risk
MM Somoza-Moncada, FJ Turrubiates-Hernández… - Nutrients, 2023 - mdpi.com
Suicide is one of the leading causes of death worldwide. According to the World Health
Organization (WHO), every year, more than 700 thousand people die from this cause …
Organization (WHO), every year, more than 700 thousand people die from this cause …
[HTML][HTML] Understanding the role of oxidative stress, neuroinflammation and abnormal myelination in excessive aggression associated with depression: recent input …
Aggression and deficient cognitive control problems are widespread in psychiatric disorders,
including major depressive disorder (MDD). These abnormalities are known to contribute …
including major depressive disorder (MDD). These abnormalities are known to contribute …
[HTML][HTML] Finding new and better treatments for psychiatric disorders
SM Paul, WZ Potter - Neuropsychopharmacology, 2024 - nature.com
In contrast to most fields of medicine, progress to discover and develop new and improved
psychiatric drugs has been slow and disappointing. The vast majority of currently prescribed …
psychiatric drugs has been slow and disappointing. The vast majority of currently prescribed …