Bone morphogenetic proteins (BMPs) and their receptors, known to be essential regulators
of embryonic patterning and organogenesis, are also critical for the regulation of …

All ectodermal organs, eg hair, teeth, and many exocrine glands, originate from two adjacent
tissue layers: the epithelium and the mesenchyme. Similar sequential and reciprocal …

Intracellular post-translational modifications such as phosphorylation and ubiquitylation
have been well studied for their roles in regulating diverse signalling pathways, but we are …

Mammalian tooth development is largely dependent on sequential and reciprocal epithelial-
mesenchymal interactions. These processes involve a series of inductive and permissive …

Heterozygous germline mutations in p63, a transcription factor of the p53 family, result in
abnormal morphogenesis of the skin and its associated structures, including hair follicles …

The spondylocostal dysostoses (SCDs) are a heterogeneous group of vertebral
malsegmentation disorders that arise during embryonic development by a disruption of …

BMP signaling is one of the key pathways regulating craniofacial development. It is involved
in the early patterning of the head, the development of cranial neural crest cells, and facial …

The rodent incisor grows continuously throughout its lifetime. The epithelial stem cell niche
is located at the apical end of the tooth and its progeny gives rise to the ameloblasts that …

FGF10 plays an important role in the morphogenesis of several tissues by control of
mesenchymal-to-epithelial signaling. In the pancreas, mesenchymal FGF10 is required to …

Runx2 (Cbfa1) is a runt domain transcription factor that is essential for bone development
and tooth morphogenesis. Teeth form as ectodermal appendages and their development is …