Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …

The p53 tumour suppressor is modified through mutation or changes in expression in most
cancers, leading to the altered regulation of hundreds of genes that are directly influenced …

In eukaryotic cells, degradation of most intracellular proteins is realized by proteasomes.
The substrates for proteolysis are selected by the fact that the gate to the proteolytic chamber …

Cancer biology finds itself in a post-genomic era and the hopes of using inherited genetic
variants to improve prevention and treatment strategies are widespread. One of the largest …

The TP53 gene is well known to be the most frequently mutated gene in human cancer. In
addition to mutations, there are> 20 different coding region single-nucleotide polymorphisms …

MDM2 is an oncoprotein that blocks p53 tumor suppressor-mediated transcriptional
transactivation, escorts p53 from the cell nucleus to the cytoplasm, and polyubiquitylates …

The p53 tumor suppressor pathway is central both in reducing cancer frequency in
vertebrates and in mediating the response of commonly used cancer therapies. This article …

A paper by Bond et al. reported that a single-nucleotide polymorphism (SNP) in the intronic
promoter region of the mouse double minute 2 (MDM2) gene (called SNP309) can …

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in the United
States. The African (AA) descent has greater incidence and mortality rates of PCa as …

With the recent explosion in high-throughput genotyping technology, the amount and quality
of SNP data have increased exponentially, facilitating the discovery of multiple uncommon …