The nucleophilic addition of carbon nucleophiles to amides has traditionally been a difficult
task, both due to reactivity and selectivity problems. When successful, these processes …

Nucleophilic addition to amides has been recognized as a promising transformation for total
synthesis of complex alkaloids. Amides can accept two different organometallic reagents …

As one of the most powerful trifluoromethylation reagents,(trifluoromethyl) trimethylsilane
(TMSCF3) has been widely used for the synthesis of fluorine-containing molecules …

A new iridium‐catalyzed reductive Strecker reaction for the direct and efficient formation of α‐
amino nitrile products from a broad range of (hetero) aromatic and aliphatic tertiary amides …

A chemoselective approach for the total synthesis of (±)‐gephyrotoxin has been developed.
The key to success was the utilization of N‐methoxyamides, which enabled the direct …

Iridium-catalyzed reductive nucleophilic addition to N-methoxyamides is reported. The
reaction took place in high yields in the presence of a variety of sensitive functional groups …

An amide group is one of the most abundant functional groups in organic synthesis.
However, nucleophilic addition to amide carbonyls has received less attention than their …

As the complexity of targeted molecules increases in modern organic synthesis,
chemoselectivity is recognized as an important factor in the development of new …

Amides are a class of highly stable and readily available compounds. The amide functional
group constitutes a class of powerful directing/activating and protecting group for C C bond …

A one-pot reaction for the transformation of common secondary amides into amines with C–
C bond formation is described. This method consists of in situ amide activation with Tf2O …