Vascular endothelial growth factor: a neurovascular target in neurological diseases
C Lange, E Storkebaum, CR De Almodóvar… - Nature Reviews …, 2016 - nature.com
Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …
Role of melatonin in controlling angiogenesis under physiological and pathological conditions
Q Ma, RJ Reiter, Y Chen - Angiogenesis, 2020 - Springer
Angiogenesis depends on proangiogenic and anti-angiogenic molecules that regulate
endothelial cell proliferation and migration. Well-regulated angiogenesis plays a pivotal role …
endothelial cell proliferation and migration. Well-regulated angiogenesis plays a pivotal role …
SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia
SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 recepto... : PAIN SARS-CoV-2 spike
protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia : PAIN …
protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia : PAIN …
[HTML][HTML] Targeting VEGF in eye neovascularization: What's new?: A comprehensive review on current therapies and oligonucleotide-based interventions under …
Roughly ten years ago the FDA approved most of the presently used anti-VEGF drugs for the
treatment of neovascular AMD and other eye pathologies characterized by ocular …
treatment of neovascular AMD and other eye pathologies characterized by ocular …
Neuroprotective factors of the retina and their role in promoting survival of retinal ganglion cells: a review
E Fudalej, M Justyniarska, K Kasarełło… - Ophthalmic …, 2021 - karger.com
Retinal ganglion cells (RGCs) play a crucial role in the visual pathway. As their axons form
the optic nerve, apoptosis of these cells causes neurodegenerative vision loss. RGC death …
the optic nerve, apoptosis of these cells causes neurodegenerative vision loss. RGC death …
[HTML][HTML] Relationships between neurodegeneration and vascular damage in diabetic retinopathy
MG Rossino, M Dal Monte, G Casini - Frontiers in Neuroscience, 2019 - frontiersin.org
Diabetic retinopathy (DR) is a common complication of diabetes and constitutes a major
cause of vision impairment and blindness in the world. DR has long been described …
cause of vision impairment and blindness in the world. DR has long been described …
Reactive oxygen species-mediated damage of retinal neurons: Drug development targets for therapies of chronic neurodegeneration of the retina
LJ Rohowetz, JG Kraus, P Koulen - International Journal of Molecular …, 2018 - mdpi.com
The significance of oxidative stress in the development of chronic neurodegenerative
diseases of the retina has become increasingly apparent in recent years. Reactive oxygen …
diseases of the retina has become increasingly apparent in recent years. Reactive oxygen …
VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody
L Micheli, C Parisio, E Lucarini, A Vona, A Toti… - Journal of Experimental …, 2021 - Springer
Background Neuropathic pain is a clinically relevant adverse effect of several anticancer
drugs that markedly impairs patients' quality of life and frequently leads to dose reduction or …
drugs that markedly impairs patients' quality of life and frequently leads to dose reduction or …
Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma
MV Gammons, R Lucas, R Dean, SE Coupland… - British journal of …, 2014 - nature.com
Background: Current therapies for metastatic melanoma are targeted either at cancer
mutations driving growth (eg, vemurafenib) or immune-based therapies (eg, ipilimumab) …
mutations driving growth (eg, vemurafenib) or immune-based therapies (eg, ipilimumab) …