Various frameworks and methods, such as quality by design (QbD), real time release test
(RTRT), and continuous process verification (CPV), have been introduced to improve drug …

Continuous drug product manufacturing is slowly being implemented in the pharmaceutical
industry. Although the benefits related to the quality and cost of continuous manufacturing …

Since the Handbook of Pharmaceutical Granulation Technology, first and second editions,
were published, there have been rapid developments in the science of granulation, particle …

Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of
tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted …

Current trends in pharmaceutical wet granulation have been shifted from traditional
approach to systematic and modern approaches, enabling the production of highly …

In this work, a mechanistic fluidized bed drying model computing the granule moisture
content in function of granule size, drying time, process settings and formulation properties is …

In view of growing interest and investment in continuous manufacturing, the development
and utilization of mathematical model (s) of the manufacturing line is of prime importance …

Continuous twin screw wet granulation is one of the key continuous manufacturing
technologies that have gained significant interest in the pharmaceutical industry as well as …

The effect of a wide variety of binders on the quality of granules produced via continuous
twin screw wet granulation was studied. Anhydrous dicalcium phosphate was used as …

Purpose This study aimed to use machine learning to predict the quality of a drug product
prepared through continuous manufacturing. Methods A design of experiment (DoE) was …