ABSTRACT Carbon/nitrogen (C/N) balance sensing is a key requirement for the
maintenance of cellular homeostasis. Therefore, cyanobacteria have evolved a …

The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or
oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic …

Carbon and nitrogen are the two most abundant nutrient elements for all living organisms,
and their metabolism is tightly coupled. What are the signaling mechanisms that cells use to …

Trans-acting regulators provide novel opportunities to study essential genes and regulate
metabolic pathways. We have adapted the clustered regularly interspersed palindromic …

Photosynthetic cyanobacteria are important primary producers and model organisms for
studying photosynthesis and elements cycling on earth. Due to the ability to absorb sunlight …

Cyanobacteria are one of the earliest branching groups of organisms on the planet, and
during their evolutionary history were submitted to varying selective pressures. Nowadays …

Cyanophycin is a carbon/nitrogen storage polymer widely distributed in most cyanobacterial
strains and in a few heterotrophic bacteria. It is a nonribosomal polypeptide consisting of …

Glutamine synthetase (GS), a key enzyme in biological nitrogen assimilation, is regulated in
multiple ways in response to varying nitrogen sources and levels. Here we show a small …

As the key enzyme of bacterial nitrogen assimilation, glutamine synthetase (GS) is tightly
regulated. In cyanobacteria, GS activity is controlled by the interaction with inactivating …

Cyanobacteria evolved sophisticated mechanisms allowing them to cope with
environmental depletion of combined nitrogen. Here, we describe progress in …