Glycogen synthase kinase‐3 (GSK‐3), an important component of the glycogen metabolism
pathway, is highly expressed in the CNS. It has been implicated in major neurological …

The accumulation of evidence implicating a role for adenosine in the pathogenesis of
asthma has led to investigations into all adenosine receptor subtypes as potential …

Adenosine administration by inhalation elicits concentration-related bronchoconstriction in
subjects with asthma and chronic obstructive pulmonary disease (COPD). The mechanisms …

Background Epidemiological evidence has suggested a link between beta‐agonists and
increases in asthma mortality. There has been much debate about possible causal links for …

Background Epidemiological evidence has suggested a link between beta 2‐agonists and
increases in asthma mortality. There has been much debate about possible causal links for …

Preformed and newly generated mediators released from airway mast cells may play a role
in adenosine-induced bronchoconstriction. To investigate the possible role of mast-cell …

Background For adults with asthma that is poorly controlled on inhaled corticosteroids (ICS),
guidelines suggest adding a long‐acting beta 2‐agonist (LABA). The LABA can be taken …

Adenosine is a ubiquitous molecule present in every cell of the human body. It has a wide
range of physiological functions mediated predominantly through specific cell surface …

Although the bronchodilator action of β 2-adrenoceptor agonists in asthma is largely due to
relaxation of airway smooth muscle, these agents have other effects which may contribute to …

Background Two large surveillance studies in adults with asthma have found an increased
risk of asthma‐related mortality in those who took regular salmeterol as monotherapy in …