The biology of CRISPR-Cas: backward and forward
F Hille, H Richter, SP Wong, M Bratovič, S Ressel… - Cell, 2018 - cell.com
In bacteria and archaea, clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Pseudomonas aeruginosa is an opportunistic pathogen affecting immunocompromised
patients. It is known as the leading cause of morbidity and mortality in cystic fibrosis (CF) …
patients. It is known as the leading cause of morbidity and mortality in cystic fibrosis (CF) …
[HTML][HTML] Phages and their satellites encode hotspots of antiviral systems
Bacteria carry diverse genetic systems to defend against viral infection, some of which are
found within prophages where they inhibit competing viruses. Phage satellites pose …
found within prophages where they inhibit competing viruses. Phage satellites pose …
[HTML][HTML] Biology and applications of CRISPR systems: harnessing nature's toolbox for genome engineering
Bacteria and archaea possess a range of defense mechanisms to combat plasmids and viral
infections. Unique among these are the CRISPR-Cas (clustered regularly interspaced short …
infections. Unique among these are the CRISPR-Cas (clustered regularly interspaced short …
CRISPR-Cas: biology, mechanisms and relevance
F Hille, E Charpentier - … of the royal society B: biological …, 2016 - royalsocietypublishing.org
Prokaryotes have evolved several defence mechanisms to protect themselves from viral
predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their …
predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their …
Inhibition of CRISPR-Cas9 with bacteriophage proteins
Bacterial CRISPR-Cas systems utilize sequence-specific RNA-guided nucleases to defend
against bacteriophage infection. As a countermeasure, numerous phages are known that …
against bacteriophage infection. As a countermeasure, numerous phages are known that …
Anti-CRISPR: discovery, mechanism and function
CRISPR–Cas adaptive immune systems are widespread among bacteria and archaea.
Recent studies have shown that these systems have minimal long-term evolutionary effects …
Recent studies have shown that these systems have minimal long-term evolutionary effects …
Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies
Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have …
associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have …
Spatiotemporal control of CRISPR/Cas9 gene editing
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein
9 (CRISPR/Cas9) gene editing technology, as a revolutionary breakthrough in genetic …
9 (CRISPR/Cas9) gene editing technology, as a revolutionary breakthrough in genetic …
[HTML][HTML] The CRISPR-Cas immune system: biology, mechanisms and applications
Viruses are a common threat to cellular life, not the least to bacteria and archaea who
constitute the majority of life on Earth. Consequently, a variety of mechanisms to resist virus …
constitute the majority of life on Earth. Consequently, a variety of mechanisms to resist virus …