The cardiovascular and other actions of angiotensin II (Ang II) are mediated by AT1 and AT2
receptors, which are seven transmembrane glycoproteins with 30% sequence similarity …

Immune cells enter the central nervous system (CNS) from the circulation under normal
conditions for immunosurveillance and in inflammatory neurologic diseases. This review …

THERE are two major angiotensin II receptor isoforms, AT1 and AT2. AT1 mediates the well-
known pressor and mitogenic effects of angiotensin II (refs 1-5), but the signalling …

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

There are two major isoforms of the angiotensin II receptor, type 1 (AT1) and type 2 (AT2).
AT2 is distinguished from AT1 with respect to its ligand selectivity, its insensitivity to non …

T he renin-angiotensin system is one of the major regulators of blood pressure and fluid and
electrolyte homeostasis. Its primary components are 1) angiotensinogen, a large globular …

I. Introduction A ngiotensin (ANG II) was discovered about 50 yr ago (1, 2), and a complete
peripheral system for the formation and metabolism of ANG II was soon characterized. It was …

Several lines of clinical and experimental evidence suggest an important role of the
reninangiotensin system in ischemic brain injury although the cellular regulation of the …

Gene therapy has become a promising approach for neurodegenerative disease treatment,
however there is an urgent need to develop an efficient gene carrier to transport gene …

Renin was first isolated in the kidney by Tigerstedt and Bergman over 100 years ago. Almost
50 additional years were necessary to isolate the renin substrate angiotensinogen and to …