T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that
recognize short peptide antigens presented on major histocompatibility complex (MHC) …

Since its first application to antibody engineering 15years ago, yeast display technology has
been developed into a highly potent tool for both affinity maturing lead molecules and …

In order to survey a universe of major histocompatibility complex (MHC)-presented peptide
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …

Yeast surface display is a powerful technology for engineering a broad range of protein
scaffolds. This protocol describes the process for de novo isolation of protein binders from …

Biocatalysts, especially enzymes, have the ability to catalyze reactions with high product
selectivity, utilize a broad range of substrates, and maintain activity at low temperature and …

Protein therapeutics is a rapidly growing segment of the pharmaceutical market. Currently,
the majority of protein therapeutics are manufactured in mammalian cells for their ability to …

The recognition of T‐cell receptor (TCR) on the surface of T cell to specific epitope
presented by the major histocompatibility complex is the key to trigger the immune response …

CD4+ T cells orchestrate adaptive immune responses via binding of antigens to their
receptors through specific peptide/MHC-II complexes. To study these responses, it is …

Directed evolution has become a well-established tool for improving proteins and biological
systems. A critical aspect of directed evolution is the selection of a suitable host organism for …

Molecular diversity lies at the heart of adaptive immunity. T‐cell receptors and peptide‐major
histocompatibility complex molecules utilize and rely upon an enormous degree of diversity …