The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell
proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy …

Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

Cancer stem cells (CSCs) contribute to the initiation, recurrence, and metastasis of cancer;
however, there are still no drugs targeting CSCs in clinical application. There are several …

Computational drug repositioning or repurposing is a promising and efficient tool for
discovering new uses from existing drugs and holds the great potential for precision …

Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of
Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for …

The repositioning or “repurposing” of existing therapies for alternative disease indications is
an attractive approach that can save significant investments of time and money during drug …

Glioblastomas (GBM) grow in a rich neurochemical milieu, but the impact of neurochemicals
on GBM growth is largely unexplored. We interrogated 680 neurochemical compounds in …

The publication of the “Molecular Testing Guideline for Selection of Lung Cancer Patients for
EGFR and ALK Tyrosine Kinase Inhibitors: Guideline From the College of American …

Millions of Americans are affected by rare diseases, many of which have poor survival rates.
However, the small market size of individual rare diseases, combined with the time and …