Leishmanization (LZ) is an intradermal inoculation of live Leishmania to induce an artificial
cutaneous leishmaniasis (CL) lesion in a covered part of the body to protect against further …

Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …

Leishmaniasis is one of the major public health concerns in Latin America, Africa, Asia, and
Europe. The absence of vaccines for human use and the lack of effective vector control …

Background Antimonial drugs have long been the mainstay to treat visceral leishmaniasis.
Their use has been discontinued in the Indian subcontinent because of drug resistance, but …

Leishmania is a unicellular protozoan that has a limited transcriptional control and mostly
uses post-transcriptional regulation of gene expression, although the molecular …

Cutaneous Leishmaniasis (CL) is a neglected tropical disease, classified by the World
Health Organization (WHO) as one of the most unrestrained diseases. The Syrian war and …

Background: We aimed to investigate the effect of miR-15a mimic and inhibitor of miR-155
expression on apoptosis induction in macrophages infected with Iranian strain of …

Elimination programs targeting TriTryp diseases (Leishmaniasis, Chagas' disease, human
African trypanosomiasis) significantly reduced the number of cases. Continued surveillance …

Background Leishmaniasis is a neglected tropical disease caused by several species of
Leishmania. The resistance phenotype of these parasites depends on the characteristics of …

Leishmania parasites efficiently develop resistance against several types of drugs including
antimonials, the primary antileishmanial drug historically implemented. The resistance to …