Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
Structure, function and drug discovery of GPCR signaling
L Cheng, F Xia, Z Li, C Shen, Z Yang, H Hou… - Molecular …, 2023 - Springer
G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …
array of physiological processes and responses, such as sensory perception (eg, vision …
JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
A Sarapultsev, E Gusev, M Komelkova, I Utepova… - Molecular …, 2023 - Springer
The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …
as a cornerstone in cellular signaling, regulating physiological and pathological processes …
Targeting Microglia in Neuroinflammation: H3 Receptor Antagonists as a Novel Therapeutic Approach for Alzheimer's Disease, Parkinson's Disease, and Autism …
Histamine performs dual roles as an immune regulator and a neurotransmitter in the
mammalian brain. The histaminergic system plays a vital role in the regulation of …
mammalian brain. The histaminergic system plays a vital role in the regulation of …
Pathology of pain and its implications for therapeutic interventions
B Cao, Q Xu, Y Shi, R Zhao, H Li, J Zheng… - … and Targeted Therapy, 2024 - nature.com
Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …
health and economic burdens. Effective pain management is crucial for individuals suffering …
[HTML][HTML] Allosteric crosstalk in modular proteins: Function fine-tuning and drug design
S Abhishek, W Deeksha, KR Nethravathi… - Computational and …, 2023 - Elsevier
Modular proteins are regulatory proteins that carry out more than one function. These
proteins upregulate or downregulate a biochemical cascade to establish homeostasis in …
proteins upregulate or downregulate a biochemical cascade to establish homeostasis in …
First report on chemometrics-driven multilayered lead prioritization in addressing oxysterol-mediated overexpression of G protein-coupled receptor 183
A Bhattacharjee, S Kar, PK Ojha - Molecular Diversity, 2024 - Springer
Contemporary research has convincingly demonstrated that upregulation of G protein-
coupled receptor 183 (GPR183), orchestrated by its endogenous agonist, 7α, 25 …
coupled receptor 183 (GPR183), orchestrated by its endogenous agonist, 7α, 25 …
An evaluation of recent advancements in biological sensory organ-inspired neuromorphically tuned biomimetic devices
In the field of neuroscience, significant progress has been made regarding how the brain
processes information. Unlike computer processors, the brain comprises neurons and …
processes information. Unlike computer processors, the brain comprises neurons and …
Investigating neuron degeneration in huntington's disease using RNA-Seq based transcriptome study
Huntington's disease (HD) is a progressive neurodegenerative disorder caused due to a
CAG repeat expansion in the huntingtin (HTT) gene. The primary symptoms of HD include …
CAG repeat expansion in the huntingtin (HTT) gene. The primary symptoms of HD include …
cAMP-PKA signaling pathway and anxiety: Where do we go next?
D Chen, J Wang, J Cao, G Zhu - Cellular Signalling, 2024 - Elsevier
Cyclic adenosine monophosphate (cAMP) is an intracellular second messenger that is
derived from the conversion of adenosine triphosphate catalysed by adenylyl cyclase (AC) …
derived from the conversion of adenosine triphosphate catalysed by adenylyl cyclase (AC) …