Research progress on the circRNA/lncRNA-miRNA-mRNA axis in gastric cancer
X Zeng, J Xiao, X Bai, Y Liu, M Zhang, J Liu… - … -Research and Practice, 2022 - Elsevier
Gastric cancer is one of the most common malignant tumours worldwide. Genetic and
epigenetic alterations are key factors in gastric carcinogenesis and drug resistance to …
epigenetic alterations are key factors in gastric carcinogenesis and drug resistance to …
Cancer associated fibroblasts-an impediment to effective anti-cancer T cell immunity
L Koppensteiner, L Mathieson, RA O'Connor… - Frontiers in …, 2022 - frontiersin.org
The presence of functionally efficient cytotoxic T lymphocytes (CTL) in the Tumour nest is
crucial in mediating a successful immune response to cancer. The detection and elimination …
crucial in mediating a successful immune response to cancer. The detection and elimination …
Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment
Z Thomson, Z He, E Swanson, K Henderson… - Nature …, 2023 - nature.com
Age-associated changes in the T cell compartment are well described. However, limitations
of current single-modal or bimodal single-cell assays, including flow cytometry, RNA-seq …
of current single-modal or bimodal single-cell assays, including flow cytometry, RNA-seq …
miR-15/16 restrain memory T cell differentiation, cell cycle, and survival
Coordinate control of T cell proliferation, survival, and differentiation are essential for host
protection from pathogens and cancer. Long-lived memory cells, whose precursors are …
protection from pathogens and cancer. Long-lived memory cells, whose precursors are …
The lncRNA Malat1 inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formation
BD Wheeler, JD Gagnon, WS Zhu, P Muñoz-Sandoval… - Elife, 2023 - elifesciences.org
Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor
CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers …
CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers …
Tumor fibroblast–derived FGF2 regulates expression of SPRY1 in esophageal tumor–infiltrating T cells and plays a role in T-cell exhaustion
Q Chen, Y Li, X Wang, X Zhang, Y Hu, L Li, D Suo, K Ni… - Cancer Research, 2020 - AACR
T-cell exhaustion was initially identified in chronic infection in mice and was subsequently
described in humans with cancer. Although the distinct signature of exhausted T (TEX) cells …
described in humans with cancer. Although the distinct signature of exhausted T (TEX) cells …
The Sprouty/Spred family as tumor suppressors: Coming of age
T Kawazoe, K Taniguchi - Cancer science, 2019 - Wiley Online Library
The Ras/Raf/ERK pathway is one of the most frequently dysregulated signaling pathways in
various cancers. In some such cancers, Ras and Raf are hotspots for mutations, which …
various cancers. In some such cancers, Ras and Raf are hotspots for mutations, which …
Loss of the orphan nuclear receptor NR2F6 enhances CD8+ T-cell memory via IFN-γ
Memory formation is a hallmark of T cell-mediated immunity, but how differentiation into
either short-lived effector cells (SLECs, CD127− KLRG1+) or memory precursors cells …
either short-lived effector cells (SLECs, CD127− KLRG1+) or memory precursors cells …
[HTML][HTML] The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response
C Jiang, J Liu, M Guo, X Gao, X Wu, N Bai… - … Journal of Biological …, 2020 - ncbi.nlm.nih.gov
Abstract Sirtuin 2 (SIRT2), an NAD+-dependent deacetylase, regulates multiple biologic and
pathologic processes including mitosis, genomic integrity, cell homeostasis and …
pathologic processes including mitosis, genomic integrity, cell homeostasis and …
Transcriptional activity and stability of CD39+ CD103+ CD8+ T cells in human high-grade endometrial cancer
HH Workel, N van Rooij, A Plat, DCJ Spierings… - International Journal of …, 2020 - mdpi.com
Tumor-infiltrating CD8+ T cells (TIL) are of the utmost importance in anti-tumor immunity.
CD103 defines tumor-resident memory T cells (TRM cells) associated with improved survival …
CD103 defines tumor-resident memory T cells (TRM cells) associated with improved survival …