Gastric cancer is one of the most common malignant tumours worldwide. Genetic and
epigenetic alterations are key factors in gastric carcinogenesis and drug resistance to …

The presence of functionally efficient cytotoxic T lymphocytes (CTL) in the Tumour nest is
crucial in mediating a successful immune response to cancer. The detection and elimination …

Age-associated changes in the T cell compartment are well described. However, limitations
of current single-modal or bimodal single-cell assays, including flow cytometry, RNA-seq …

Coordinate control of T cell proliferation, survival, and differentiation are essential for host
protection from pathogens and cancer. Long-lived memory cells, whose precursors are …

Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor
CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers …

T-cell exhaustion was initially identified in chronic infection in mice and was subsequently
described in humans with cancer. Although the distinct signature of exhausted T (TEX) cells …

The Ras/Raf/ERK pathway is one of the most frequently dysregulated signaling pathways in
various cancers. In some such cancers, Ras and Raf are hotspots for mutations, which …

Memory formation is a hallmark of T cell-mediated immunity, but how differentiation into
either short-lived effector cells (SLECs, CD127− KLRG1+) or memory precursors cells …

Abstract Sirtuin 2 (SIRT2), an NAD+-dependent deacetylase, regulates multiple biologic and
pathologic processes including mitosis, genomic integrity, cell homeostasis and …

Tumor-infiltrating CD8+ T cells (TIL) are of the utmost importance in anti-tumor immunity.
CD103 defines tumor-resident memory T cells (TRM cells) associated with improved survival …