Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Purpose This review provides an update on the current clinical, epidemiological and
pathophysiological evidence alongside the diagnostic, prevention and treatment approach …

Allodynia (pain due to a stimulus that does not usually provoke pain) and hyperalgesia
(increased pain from a stimulus that usually provokes pain) are prominent symptoms in …

Following the serendipitous discovery of the anticancer activity of cisplatin over 50 years
ago, a deep understanding of the chemical and biochemical transformations giving rise to its …

Patients treated with platinum-based chemotherapy frequently experience neurotoxic
symptoms, which may lead to premature discontinuation of therapy. Despite discontinuation …

Purpose The aim of this study was to systematically review the literature on the influence of
oxaliplatin administration (eg cumulative dose, dose intensity, number of cycles and …

Oxaliplatin is an integral component of colorectal cancer therapy, but its clinical use is
associated with a dose-limiting peripheral neurotoxicity. We found that the organic cation …

Cold allodynia, pain in response to cooling, occurs during or within hours of oxaliplatin
infusion and is thought to arise from a direct effect of oxaliplatin on peripheral sensory …

This trial assessed the efficacy of MR309 (a novel selective sigma-1 receptor ligand
previously developed as E-52862) in ameliorating oxaliplatin-induced peripheral …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer
therapy. This study evaluates symptoms of CIPN and CIPN-related pain and its influence on …