There is both epidemiologic and experimental evidence that the long-chain omega-3 fatty
acids (FAs), which occur at high levels in some fish oils, exert protective effects against some …

Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and
inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of …

Flavopiridol inhibits phosphokinases. Its activity is strongest on cyclin dependent kinases
(cdk-1,-2,-4,-6,-7) and less on receptor tyrosine kinases (EGFR), receptor associates …

Convincing evidence is available showing that dietary calcium and vitamin D impede the
development of colonic carcinogenesis. The major cellular modes of action of calcium and …

Compiling significant advances from more than a decade of research, this text presents
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …

Protein kinase C (PKC) is a family of closely related lipid-dependent and diacyglycerol-
activated isoenzymes known to play an important role in the signal transduction pathways …

The outcome of cancer metastasis depends on the interaction of metastatic cells with various
host factors. The implantation of human cancer cells into anatomically correct (orthotopic) …

Introduction 2.1. The Protein Kinase C Family: Role in Cell Growth Control 3. Discussion 3.1.
Effects of PKC activation on cell cycle progression 3.2. Mechanisms of PKC-mediated cell …

Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce
phosphatidic acid (PA) and choline. PLD is a major enzyme implicated in important cellular …

Many investigators have embarked upon the search for novel cellular targets for the
treatment of cancer. A popular therapeutic strategy is to intervene with the components of …