The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal
released from the presynaptic terminal and transduce it into electrical and biochemical …

Synapse regulation exploits the capacity of actin to function as a stable structural component
or as a dynamic filament. Beyond its well-appreciated role in eliciting visible morphological …

One of the unique characteristics of higher organisms is their ability to learn and adapt to
changes in their environment. This plasticity is largely a result of the brain's ability to convert …

Summary SynGAP is a Ras-GTPase activating protein highly enriched at excitatory
synapses in the brain. Previous studies have shown that CaMKII and the RAS-ERK pathway …

In the nervous system, many intracellular responses to elevated calcium are mediated by
CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by …

Synaptic spines are dynamic structures that regulate neuronal responsiveness and
plasticity. We examined the role of the schizophrenia risk factor DISC1 in the maintenance of …

Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) is the activating kinase for
multiple downstream kinases, including CaM-kinase I (CaMKI), CaM-kinase IV (CaMKIV) …

Neuronal activity induces intracellular Ca2+ increase, which triggers activation of a series of
Ca2+‐dependent signaling cascades. Among these, the multifunctional Ca2+/calmodulin …

Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of
Alzheimer's disease (AD), but most abnormally expressed miRNAs found in AD are not …