The emergence of phase separation as an organizing principle in bacteria
Recent investigations in bacteria suggest that membraneless organelles play a crucial role
in the subcellular organization of bacterial cells. However, the biochemical functions and …
in the subcellular organization of bacterial cells. However, the biochemical functions and …
Making the case for disordered proteins and biomolecular condensates in bacteria
Intrinsically disordered proteins/regions (IDPs/IDRs) contribute to a diverse array of
molecular functions in eukaryotic systems. There is also growing recognition that …
molecular functions in eukaryotic systems. There is also growing recognition that …
Cryogenic single-molecule fluorescence annotations for electron tomography reveal in situ organization of key proteins in Caulobacter
PD Dahlberg, S Saurabh, AM Sartor… - Proceedings of the …, 2020 - National Acad Sciences
Superresolution fluorescence microscopy and cryogenic electron tomography (CET) are
powerful imaging methods for exploring the subcellular organization of biomolecules …
powerful imaging methods for exploring the subcellular organization of biomolecules …
How important is protein diffusion in prokaryotes?
PE Schavemaker, AJ Boersma… - Frontiers in molecular …, 2018 - frontiersin.org
That diffusion is important for the proper functioning of cells is without question. The extent to
which the diffusion coefficient is important is explored here for prokaryotic cells. We discuss …
which the diffusion coefficient is important is explored here for prokaryotic cells. We discuss …
Selective sequestration of signalling proteins in a membraneless organelle reinforces the spatial regulation of asymmetry in Caulobacter crescentus
Selective recruitment and concentration of signalling proteins within membraneless
compartments is a ubiquitous mechanism for subcellular organization,–. The dynamic flow of …
compartments is a ubiquitous mechanism for subcellular organization,–. The dynamic flow of …
Phase separation modulates the assembly and dynamics of a polarity-related scaffold-signaling hub
Asymmetric cell division (ACD) produces morphologically and behaviorally distinct cells and
is the primary way to generate cell diversity. In the model bacterium Caulobacter crescentus …
is the primary way to generate cell diversity. In the model bacterium Caulobacter crescentus …
ATP-responsive biomolecular condensates tune bacterial kinase signaling
S Saurabh, TN Chong, C Bayas, PD Dahlberg… - Science …, 2022 - science.org
Biomolecular condensates formed via liquid-liquid phase separation enable spatial and
temporal organization of enzyme activity. Phase separation in many eukaryotic condensates …
temporal organization of enzyme activity. Phase separation in many eukaryotic condensates …
Biomolecular condensates as stress sensors and modulators of bacterial signaling
M Sasazawa, DT Tomares, WS Childers… - Plos …, 2024 - journals.plos.org
Microbes exhibit remarkable adaptability to environmental fluctuations. Signaling
mechanisms, such as two-component systems and secondary messengers, have long been …
mechanisms, such as two-component systems and secondary messengers, have long been …
Regulation of the activity of the bacterial histidine kinase PleC by the scaffolding protein PodJ
Scaffolding proteins can customize the response of signaling networks to support cell
development and behaviors. PleC is a bifunctional histidine kinase whose signaling activity …
development and behaviors. PleC is a bifunctional histidine kinase whose signaling activity …
A bacterial toxin perturbs intracellular amino acid balance to induce persistence
Bacterial cells utilize toxin-antitoxin systems to inhibit self-reproduction, while maintaining
viability, when faced with environmental challenges. The activation of the toxin is often …
viability, when faced with environmental challenges. The activation of the toxin is often …