The p53-related genes p63 and p73 exhibit significant structural homology to p53; however,
they do not function as classical tumor suppressors and are rarely mutated in human …

The p53-related protein p63 has pleiotropic functions, including cell proliferation, survival,
apoptosis, differentiation, senescence, and aging. The p63 gene is expressed as multiple …

Myoepithelial cells (MCs) constitute the basal cell layer of normal mammary epithelia, and
their identification is of particular diagnostic value because they are retained in most benign …

Abstract p63 is distinct from its homologue p53 in that its role as a tumour suppressor is
controversial, an issue complicated by the existence of two classes of p63 isoforms. Here we …

The p63 gene encodes at least six different proteins with homology to the tumour suppressor
protein p53 and the related p53 family member p73. So far, there have been limited data …

Abstract p63, a recently identified member of the p53 gene family, encodes multiple products
with transactivating, death-inducing, and dominant-negative activities. To explore the …

Purpose: p63 is proposed to play roles in normal development and differentiation of stratified
epithelia including urothelium. We recently reported that impaired p63 expression is a …

TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein
isoforms through multiple mechanisms including extensive alternative mRNA splicing …

Acute lymphoblastic leukemia (ALL) is a malignant disease of the white blood cells. The
etiology of ALL is believed to be multifactorial and likely to involve an interplay of …

Hepatoblastoma (HBL) is the most common malignant liver tumor in young children. Recent
reports have shown that the β-catenin gene was frequently mutated or deleted in HBLs. To …