Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

A bio-based economy has the potential to provide sustainable substitutes for petroleum-
based products and new chemical building blocks for advanced materials. We previously …

Global climate change linked to the accumulation of greenhouse gases has caused
concerns regarding the use of fossil fuels as the major energy source. To mitigate climate …

CO2 sequestration engineering is an attractive strategy for achieving carbon-and energy-
efficient bioproduction. However, the efficiency of heterotrophic CO2 sequestration is limited …

The design and optimization of biosynthetic pathways for industrially relevant, non-model
organisms is challenging due to transformation idiosyncrasies, reduced numbers of …

Acetyl-CoA is a fundamental metabolite for all life on Earth, and is also a key starting point
for the biosynthesis of a variety of industrial chemicals and natural products. Here we design …

Highlights•Formate is an ideal mediator between the physicochemical and biological
realms.•Formate can be efficiently produced from various highly available …

Highlights•Non-conventional feedstocks can contribute to a circular chemical industry.•Non-
conventional feedstocks open stoichiometric opportunities for niche applications.•Plastic …

To integrate heterogeneous and large omics data constitutes not only a conceptual
challenge but a practical hurdle in the daily analysis of omics data. With the rise of novel …