RAS and BRAF-mutated colorectal cancers are associated with resistance to chemotherapy
and poor prognosis, highlighting the need for new therapeutic strategies. Although these …

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for
the Investigation of Novel Anti-Cancer Therapies - JoVE JoVE JoVE Faculty Resource …

Abstract Background Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is a key
regulator of multiple stages of mitotic progression. Plk1 is upregulated in many tumor types …

Abstract Human 15-lipoxygenase-1 (h-15-LOX-1) is a promising drug target in inflammation
and cancer. In this study substitution-oriented screening (SOS) has been used to identify …

Chamaejasmin B (CHB), a natural biflavone isolated from Stellera chamaejasme L., has
been reported to exhibit anti-cancer properties; however, its effect in melanoma cells is not …

人源性肿瘤组织异种移植(PDTX) 模型是通过将患者新鲜的肿瘤组织植入免疫缺陷小鼠,
依靠小鼠提供的微环境生长. 此模型保留了原代肿瘤的病理生理特性, 组织学和表型特征 …

Background/Aim: MEK inhibitors are new promising anticancer drugs. The aim of this study
was to investigate the effect of the combination treatment of voreloxin with the MEK inhibitor …

As a potent and selective allosteric inhibitor of MEK, TAK-733 has been shown to exert anti-
cancer effects for a wide range of cancers both in vitro and in vivo. However, its effects on …

Background: Antibody-drug conjugates (ADCs) are an emerging technology consisting of an
antibody, linker, and toxic agent, which have the potential to offer a targeted therapeutic …

BACKGROUND: Cardiac hypertrophy is an important risk factor for heart failure. The MEK-
ERK axis has been reported as a major regulator in controlling cardiac hypertrophy. TAK733 …