The amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide
in the brain is a central event in Alzheimer's disease pathology, has dominated research for …

Dementia is a clinical syndrome of widespread progressive deterioration of cognitive
abilities and normal daily functioning. These cognitive and behavioral impairments pose …

There are numerous neuropsychological tests for assessing executive functions in aging,
which vary according to the different domains assessed. OBJECTIVE: To present a …

Older adults who ultimately develop dementia experience accelerated cognitive decline
long before diagnosis. A similar acceleration in cognitive decline occurs in the years before …

Background: Data on the longitudinal association of walking pace with the risk of cognitive
decline and dementia are inconsistent and inconclusive. Therefore, researchers conducted …

Appropriate for use in developmental research methods or analysis of change courses, this
is the first methods handbook specifically designed to meet the needs of those studying …

Background. Slow walking speed has been shown to predict dementia. We investigated the
relation of walking speed, processing speed, and their changes over time to dementia …

Introduction Mapping the preclinical dementia phase is important for early detection and
evaluation of interventions. We assessed the trajectories of cognitive decline in preclinical …

Heritability studies document substantial genetic influences on cognitive performance and
decline in old age. Increasing evidence shows that effects of genetic variations on cognition …

Background Electronic linkage of UK cohorts to routinely collected National Health Service
(NHS) records provides virtually complete follow-up for cause-specific hospital admissions …