High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has
been widely reported to play a pivotal role in the pathogenesis of hematopoietic …

Significance: As a redox-sensitive protein, high-mobility group box 1 (HMGB1) is implicated
in regulating stress responses to oxidative damage and cell death, which are closely related …

The etiology of the majority of human cancers is associated with a myriad of environmental
causes, including physical, chemical, and biological factors. DNA damage induced by such …

High mobility group box 1 (HMGB1) is an extremely versatile protein that is located
predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in …

Malignant tumors often escape anticancer immune surveillance by suppressing the cytotoxic
functions of T lymphocytes. While many of these immune evasion networks include …

Dysregulation of the innate immune system and inflammatory-related pathways has been
implicated in hematopoietic defects in the bone marrow microenvironment and associated …

Macrophages constitute one of the most common components of immune cells, which
penetrate tumors and they have a key role in tumor prognosis. Here, we identified an …

The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose
interactions with DNA as well as with other proteins lead to the formation of a complicated …

Inflammation is associated with bone marrow failure syndromes, but how specific molecules
impact the bone marrow microenvironment is not well elucidated. We report a novel role for …

Galectin-9 is one of the key proteins employed by a variety of human malignancies to
suppress anti-cancer activities of cytotoxic lymphoid cells and thus escape immune …