Crossing the blood–brain barrier: recent advances in drug delivery to the brain
CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …
Tight junction modulation of the blood brain barrier: CNS delivery of small molecules
C Greene, M Campbell - Tissue barriers, 2016 - Taylor & Francis
The blood brain barrier (BBB) represents a major obstacle for targeted drug delivery to the
brain for the treatment of central nervous system (CNS) disorders. Significant advances in …
brain for the treatment of central nervous system (CNS) disorders. Significant advances in …
Tight junction proteins at the blood–brain barrier: far more than claudin-5
P Berndt, L Winkler, J Cording… - Cellular and molecular …, 2019 - Springer
At the blood–brain barrier (BBB), claudin (Cldn)-5 is thought to be the dominant tight junction
(TJ) protein, with minor contributions from Cldn3 and-12, and occludin. However, the BBB …
(TJ) protein, with minor contributions from Cldn3 and-12, and occludin. However, the BBB …
A comprehensive review in improving delivery of small-molecule chemotherapeutic agents overcoming the blood-brain/brain tumor barriers for glioblastoma treatment
Glioblastoma (GBM) is the most common and lethal primary brain tumor which is highly
resistant to conventional radiotherapy and chemotherapy, and cannot be effectively …
resistant to conventional radiotherapy and chemotherapy, and cannot be effectively …
A versatile lab-on-a-chip tool for modeling biological barriers
Abstract Models of biological barriers are important to study physiological functions,
transport mechanisms, drug delivery and pathologies. However, there are only a few …
transport mechanisms, drug delivery and pathologies. However, there are only a few …
Penetration of the SARS-CoV-2 spike protein across the blood–brain barrier, as revealed by a combination of a human cell culture model system and optical …
Since the outbreak of the global pandemic caused by severe acute respiratory coronavirus 2
(SARS-CoV-2), several clinical aspects of the disease have come into attention. Besides its …
(SARS-CoV-2), several clinical aspects of the disease have come into attention. Besides its …
Modulating the blood–brain barrier: a comprehensive review
The highly secure blood–brain barrier (BBB) restricts drug access to the brain, limiting the
molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic …
molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic …
Cyclodextrins, blood–brain barrier, and treatment of neurological diseases
Biological barriers are the main defense systems of the homeostasis of the organism and
protected organs. The blood–brain barrier (BBB), formed by the endothelial cells of brain …
protected organs. The blood–brain barrier (BBB), formed by the endothelial cells of brain …
Nose-to-Brain (N2B) Delivery: An Alternative Route for the Delivery of Biologics in the Management and Treatment of Central Nervous System Disorders
EJ Patharapankal, AL Ajiboye, C Mattern, V Trivedi - Pharmaceutics, 2023 - mdpi.com
In recent years, there have been a growing number of small and large molecules that could
be used to treat diseases of the central nervous system (CNS). Nose-to-brain delivery can …
be used to treat diseases of the central nervous system (CNS). Nose-to-brain delivery can …
Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain
W Neuhaus, A Piontek, J Protze, M Eichner… - Biomaterials, 2018 - Elsevier
The blood-brain barrier (BBB) prevents entry of neurotoxic substances but also that of drugs
into the brain. Here, the paracellular barrier is formed by tight junctions (TJs) with claudin-5 …
into the brain. Here, the paracellular barrier is formed by tight junctions (TJs) with claudin-5 …