Glutaredoxin, Grx, is a small protein containing an active site cysteine pair and was
discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione …

Oxidative stress involves the increased production and accumulation of free radicals,
peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS) …

Significance: Thioredoxin (Trx) is a powerful antioxidant that reduces protein disulfides to
maintain redox stability in cells and is involved in regulating multiple redox-dependent …

Nucleotide synthesis is a metabolically demanding process essential for DNA replication
and other processes in the cell. Several anticancer drugs that inhibit nucleotide metabolism …

From bacteria to plants and humans, the glutathione system plays a pleiotropic role in cell
defense against metabolic, oxidative and metal stresses. Glutathione (GSH), the γ-L …

Significance: The multifactorial nature of the mechanisms implicated in cancer development
still represents a major issue for the success of established antitumor therapies. The …

Radiotherapy is a standard-of-care treatment approach for glioblastoma (GBM) patients, but
therapeutic resistance to radiotherapy remains a major challenge. Here we demonstrate that …

Purpose Glutaredoxin 1 (Grx1) is a key antioxidant protein that catalyzes disulfide redox
reactions. In this study, we investigated the expression and protective effect of Grx1 against …

We recently discovered that the expression of PRKN, a young-onset Parkinson disease-
linked gene, confers redox homeostasis. To further examine the protective effects of parkin …

Nitric Oxide is a very well known gaseous second messenger molecule and vasorelaxant
agent involved in a variety of signaling in the body such as neurotransmission, ion channel …