Diacylglycerol (DAG) has unique functions as a basic component of membranes, an
intermediate in lipid metabolism and a key element in lipid-mediated signaling. In …

DGKs (diacylglycerol kinases) are members of a unique and conserved family of
intracellular lipid kinases that phosphorylate DAG (diacylglycerol), catalysing its conversion …

Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids,
DAG and phosphatidic acid (PA), by phosphorylating DAG to yield PA. To date, ten …

Anergic T cells have altered diacylglycerol metabolism, but whether that altered metabolism
has a causative function in the induction of T cell anergy is not apparent. To test the …

T cell anergy has been correlated with defective signaling by the GTPase Ras, but causal
and mechanistic data linking defective Ras activity with T cell anergy are lacking. Here we …

Protein kinase C molecules regulate both positive and negative signal transduction
pathways essential for the initiation and homeostasis of immune responses. There are …

Diacylglycerol (DAG) is an important lipid that is both an intermediate in lipid biosynthetic
pathways and can act as a signaling lipid. The majority of signaling DAG is generated by …

Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

Acetylcholine (ACh) has been shown to modulate neuronal differentiation during early
development. Both muscarinic and nicotinic acetylcholine receptors (AChRs) regulate a …

Much is known about how T cell receptor (TCR) engagement leads to T cell activation;
however, the mechanisms terminating TCR signaling remain less clear. Diacylglycerol …