Intercellular communication mediated by cytokines is the main mechanism by which cells of
the immune system talk to each other. Many aspects of cytokine signalling in the immune …

The genetic, functional or compositional heterogeneity of healthy and diseased tissues
presents major challenges in drug discovery and development. Such heterogeneity hinders …

Single-cell RNA-seq can precisely resolve cellular states, but applying this method to low-
input samples is challenging. Here, we present Seq-Well, a portable, low-cost platform for …

The existence of cellular heterogeneity and its central relevance to biological phenomena
provides a strong rationale for a need for analytical methods that enable analysis at the …

Recent advances in cellular profiling have demonstrated substantial heterogeneity in the
behaviour of cells once deemed'identical', challenging fundamental notions of …

Resolution of inflammation is a finely regulated process mediated by specialized
proresolving lipid mediators (SPMs), including docosahexaenoic acid (DHA)–derived …

Proteins are involved in many biological processes. Misfolded, truncated, or mutated
proteins as well as over-or underexpressed proteins have been implicated in many …

The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …

Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of
antigenic epitopes capable of evoking the most potent CAR activation is an important …

Cytokines are bioactive proteins produced by many different cells of the immune system.
Due to their role in different inflammatory disease states and maintaining homeostasis, there …