The most life-threatening aspects of the oncogenic process are invasion and metastasis.
Even though the clinical significance of such expression of the malignant phenotype has …

Malignancy is defined as neoplastic growth that tends to metastasize. Thus by definition
metastatic ability is the correlate of malignant potential. The fonnation of metastatic foci is the …

An aged circulatory environment can activate microglia, reduce neural precursor cell activity
and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate …

The effect of mammary gland-specific expression of the polyomavirus middle T antigen was
examined by establishing lines of transgenic mice that carry the middle T oncogene under …

Defective function of dendritic cells (DC) in cancer has been recently described and may
represent one of the mechanisms of tumor evasion from immune system control. We have …

The urokinase‐type plasminogen activator (u‐PA) system consists of the serine proteinases
plasmin and u‐PA; the serpin inhibitors α2‐anti‐plasmin, PAI‐1 and PAI‐2; and the u‐PA …

MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level in the
cytoplasm, but recent findings suggest additional roles for miRNAs in the nucleus. To …

Extracellular proteolysis is an absolute requirement for new blood vessel formation
(angiogenesis). This review examines the role of the matrix metalloproteinase (MMP) and …

Abstract Phage displaying an Arg-Gly-Asp (RGD)-containing peptide with a high affinity for
αv integrins homed to tumors when injected intravenously into tumor-bearing mice. A …

During angiogenesis, endothelial cells penetrate fibrin barriers via undefined proteolytic
mechanisms. We demonstrate that the fibrinolytic plasminogen activator (PA)-plasminogen …