The role of TRIM family proteins in autophagy, pyroptosis, and diabetes mellitus
T Wan, X Li, Y Li - Cell biology international, 2021 - Wiley Online Library
The ubiquitin‐proteasome system, which is one of the systems for cell protein homeostasis
and degradation, happens through the ordered and coordinated action of three types of …
and degradation, happens through the ordered and coordinated action of three types of …
MG53, a tissue repair protein with broad applications in regenerative medicine
Z Li, L Wang, H Yue, BA Whitson, E Haggard, X Xu… - Cells, 2021 - mdpi.com
Under natural conditions, injured cells can be repaired rapidly through inherent biological
processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy …
processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy …
MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer
Background Cancer cells develop resistance to chemotherapeutic intervention by excessive
formation of stress granules (SGs), which are modulated by an oncogenic protein G3BP2 …
formation of stress granules (SGs), which are modulated by an oncogenic protein G3BP2 …
[HTML][HTML] MG53 preserves mitochondrial integrity of cardiomyocytes during ischemia reperfusion-induced oxidative stress
Ischemic injury to the heart induces mitochondrial dysfunction due to increasing oxidative
stress. MG53, also known as TRIM72, is highly expressed in striated muscle, is secreted as …
stress. MG53, also known as TRIM72, is highly expressed in striated muscle, is secreted as …
[HTML][HTML] MG53 suppresses NF-κB activation to mitigate age-related heart failure
Aging is associated with chronic oxidative stress and inflammation that affect tissue repair
and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell …
and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell …
[HTML][HTML] Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development
MG53 is an essential component of the cell membrane repair machinery, participating in the
healing of dermal wounds. Here we develop a novel delivery system using recombinant …
healing of dermal wounds. Here we develop a novel delivery system using recombinant …
Asprosin-neutralizing antibodies as a treatment for metabolic syndrome
Background: Recently, we discovered a new glucogenic and centrally acting orexigenic
hormone–asprosin. Asprosin is elevated in metabolic syndrome (MS) patients, and its …
hormone–asprosin. Asprosin is elevated in metabolic syndrome (MS) patients, and its …
Mouse models of liver parenchyma injuries and regeneration
Y Du, W Zhang, H Qiu, C Xiao, J Shi… - Frontiers in Cell and …, 2022 - frontiersin.org
Mice have genetic and physiological similarities with humans and a well-characterized
genetic background that is easy to manipulate. Murine models have become the most …
genetic background that is easy to manipulate. Murine models have become the most …
Is MG53 a potential therapeutic target for cancer?
Y Du, T Li, M Yi - Frontiers in endocrinology, 2023 - frontiersin.org
Cancer treatment still encounters challenges, such as side effects and drug resistance. The
tripartite-motif (TRIM) protein family is widely involved in regulation of the occurrence …
tripartite-motif (TRIM) protein family is widely involved in regulation of the occurrence …
Cardiac effects and clinical applications of MG53
Heart disease remains the leading cause of mortality globally, so further investigation is
required to identify its underlying mechanisms and potential targets for treatment and …
required to identify its underlying mechanisms and potential targets for treatment and …