Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

Angiogenesis, the formation of new vessels, is found in Multiple Sclerosis (MS)
demyelinating lesions following Vascular Endothelial Growth Factor (VEGF) release and the …

The early stages of Alzheimer's disease are characterised by impaired synaptic plasticity
and synapse loss. Here, we show that amyloid-β oligomers (AβOs) activate the c-Abl kinase …

Alzheimer's disease (AD) is characterized by progressive memory loss and dementia. The
strong correlation between cognitive decline and the loss of synapses supports the idea that …

Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons
in the motor cortex, brainstem and spinal cord. It is a neurodegenerative disorder with high …

During development of the central nervous system not all axons are myelinated, and axons
may have distinct myelination patterns. Furthermore, the number of myelin sheaths formed …

Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways
that mediate cell-to-cell communication and their function as relay points for signaling …

Amyotrophic lateral sclerosis (ALS) is an untreatable, progressive, neurodegenerative
disease specifically affecting motor neurons. Recently, the tyrosine kinase receptor EphA4 …

In the central nervous system, myelination of axons is required to ensure fast saltatory
conduction and for survival of neurons. However, not all axons are myelinated, and the …

In patients with multiple sclerosis (MS) and mice with experimental autoimmune
encephalomyelitis (EAE), inflammatory axonal injury is a major determinant of disability; …