Two faces of vitamin C—antioxidative and pro-oxidative agent
J Kaźmierczak-Barańska, K Boguszewska… - Nutrients, 2020 - mdpi.com
Vitamin C has been known for decades. It is common in everyday use as an element of the
diet, supplementation, and a preservative. For years, research has been conducted to …
diet, supplementation, and a preservative. For years, research has been conducted to …
DNA methylation methods: Global DNA methylation and methylomic analyses
S Li, TO Tollefsbol - Methods, 2021 - Elsevier
DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …
significant involvement for numerous biological processes in health and disease. The …
The roles of human DNA methyltransferases and their isoforms in shaping the epigenome
A DNA sequence is the hard copy of the human genome and it is a driving force in
determining the physiological processes in an organism. Concurrently, the chemical …
determining the physiological processes in an organism. Concurrently, the chemical …
5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation
In mammals, cytosine methylation (5mC) is widely distributed throughout the genome but is
notably depleted from active promoters and enhancers. While the role of DNA methylation in …
notably depleted from active promoters and enhancers. While the role of DNA methylation in …
l-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer
Through unbiased metabolomics, we identified elevations of the metabolite 2-
hydroxyglutarate (2HG) in renal cell carcinoma (RCC). 2HG can inhibit 2-oxoglutaratre (2 …
hydroxyglutarate (2HG) in renal cell carcinoma (RCC). 2HG can inhibit 2-oxoglutaratre (2 …
DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies
AP Im, AR Sehgal, MP Carroll, BD Smith, A Tefferi… - Leukemia, 2014 - nature.com
The development of effective treatment strategies for most forms of acute myeloid leukemia
(AML) has languished for the past several decades. There are a number of reasons for this …
(AML) has languished for the past several decades. There are a number of reasons for this …
Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine
Vitamin C deficiency is found in patients with cancer and might complicate various therapy
paradigms. Here we show how this deficiency may influence the use of DNA …
paradigms. Here we show how this deficiency may influence the use of DNA …
Targeting epigenetics: A novel promise for Alzheimer's disease treatment
D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
Epigenetic regulation mechanisms of microRNA expression
MicroRNAs (miRNAs) are single-stranded RNAs of 18–25 nucleotides that regulate gene
expression at the post-transcriptional level. They are involved in many physiological and …
expression at the post-transcriptional level. They are involved in many physiological and …
TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway
Ten eleven translocation (TET) enzymes catalyse the oxidative reactions of 5-methylcytosine
(5mC) to promote the demethylation process. The reaction intermediate 5 …
(5mC) to promote the demethylation process. The reaction intermediate 5 …