An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …

Erythropoiesis is a multi‐step process that involves the differentiation of hematopoietic stem
cells into mature red blood cells (RBCs). This process is regulated by several signaling …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Background: Current differentiation protocols to produce cardiomyocytes from human
induced pluripotent stem cells (iPSCs) are capable of generating highly pure cardiomyocyte …

Anemia in β-thalassemia is related to ineffective erythropoiesis and reduced red cell
survival. Excess free heme and accumulation of unpaired α-globin chains impose …

Advances in genomic profiling present new challenges of explaining how changes in DNA
and RNA are translated into proteins linking genotype to phenotype. Here we compare the …

Complex regulation of the immune response is necessary to support effective defense of an
organism against hostile invaders and to maintain tolerance to harmless microorganisms …

Thalassemia (thal) is an autosomal recessive, hereditary, chronic hemolytic anemia due to a
partial or complete deficiency in the synthesis of α-globin chains (α-thal) or β-globin chains …

FOXO family of proteins are transcription factors involved in many physiological and
pathological processes including cellular homeostasis, stem cell maintenance, cancer …

As essential components of hemoglobin, iron and heme play central roles in terminal
erythropoiesis. The impairment of this process in iron/heme deficiency results in microcytic …