Quercetin and derivatives: useful tools in inflammation and pain management

G Carullo, AR Cappello, L Frattaruolo… - Future medicinal …, 2017 - Taylor & Francis
Inflammation represents a very frequent condition in humans; it is often underestimated,
making the problem an increasingly alarming phenomenon. For these reasons …

[HTML][HTML] Medicinal herbs in the treatment of neuropathic pain: a review

F Forouzanfar, H Hosseinzadeh - Iranian journal of basic medical …, 2018 - ncbi.nlm.nih.gov
Chronic neuropathic pain is a common significant and debilitating problem that presents a
major challenge to health-care. Despite the large number of available drugs, there are no …

Quercetin alleviates neuropathic pain in the rat CCI model by mediating AMPK/MAPK pathway

G Ye, C Lin, Y Zhang, Z Ma, Y Chen, L Kong… - Journal of Pain …, 2021 - Taylor & Francis
Context Quercetin (que) is one abundant flavonol with a variety of biological activities.
Previous studies have shown quercetin can reduce neuropathic pain in rats with chronic …

[HTML][HTML] In vitro and in vivo effects of flavonoids on peripheral neuropathic pain

P Basu, A Basu - Molecules, 2020 - mdpi.com
Neuropathic pain is a common symptom and is associated with an impaired quality of life. It
is caused by the lesion or disease of the somatosensory system. Neuropathic pain …

[HTML][HTML] Exploring the promise of flavonoids to combat neuropathic pain: from molecular mechanisms to therapeutic implications

MS Uddin, AA Mamun, MA Rahman, MT Kabir… - Frontiers in …, 2020 - frontiersin.org
Neuropathic pain (NP) is the result of irregular processing in the central or peripheral
nervous system, which is generally caused by neuronal injury. The management of NP …

Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats

Y Wang, W Li, M Wang, C Lin, G Li… - Journal of cellular …, 2018 - Wiley Online Library
Spinal cord injury (SCI) is lead to locomotor impairment because of neurological damage
after following trauma. Quercetin (Que) has been confirmed to have a neuro‐protective effect …

Emotional and cognitive impairments in the peripheral nerve chronic constriction injury model (CCI) of neuropathic pain: A systematic review

D Fonseca-Rodrigues, D Amorim, A Almeida… - Behavioural brain …, 2021 - Elsevier
Background and objective Emotional and cognitive impairments are common comorbidities
of chronic neuropathic pain that significantly impact the quality of life of patients. While the …

Quercetin relieved diabetic neuropathic pain by inhibiting upregulated P2X4 receptor in dorsal root ganglia

R Yang, L Li, H Yuan, H Liu, Y Gong… - Journal of Cellular …, 2019 - Wiley Online Library
The upregulation of nociceptive ion channels expressed in dorsal root ganglia (DRG)
contributes to the development and retaining of diabetic pain symptoms. The flavonoid …

[HTML][HTML] Quercetin derivatives in combating spinal cord injury: a mechanistic and systematic review

S Fakhri, MM Gravandi, S Abdian, SZ Moradi… - Life, 2022 - mdpi.com
Spinal cord injury (SCI) possesses a complicated etiology. There is no FDA-approved
treatment for SCI, and the majority of current interventions focus on reducing symptoms …

The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia

M Shahid, F Subhan, N Ahmad, RDE Sewell - Biomedicine & …, 2017 - Elsevier
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose limiting side-effect of
several commonly used chemotherapeutic agents (such as cisplatin) that profoundly impairs …