The role of serotonin in food intake has been studied for decades. Food intake is mainly
regulated by two brain circuitries:(i) the homeostatic circuitry, which matches energy intake …

Genetics in model organisms has progressively broken down walls that previously
separated different disciplines of biology. One example of this holistic evolution is the …

The mouse genetic revolution has shown repeatedly that most organs have more functions
than expected. This has led to the realization that, in addition to a molecular and cellular …

Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …

Leptin originates in adipocytes, including those in bone marrow, and circulates in
concentrations 20 to 90 times higher than those in the cerebrospinal fluid. It has direct …

Calcium (Ca 2+) is an essential ligand that binds its primary intracellular receptor calmodulin
(CaM) to trigger a variety of downstream processes and pathways. Central to the actions of …

Osteoclasts are the cells responsible for physiological bone resorption. A specific
organization of their most prominent cytoskeletal structures, podosomes, is crucial for the …

The metabolic dysfunctions induced by high fat diet (HFD) consumption are not limited to
organs involved in energy metabolism but cause also a chronic low-grade systemic …

Objective: Osteoimmunology investigates interactions between skeleton and immune
system. In the light of recent discoveries in this field, a new reading register of osteoporosis …

Maintenance of energy balance requires regulation of the amount and timing of food intake.
Decades of experiments utilizing pharmacological and later genetic manipulations have …