GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

Ketamine exerts rapid antidepressant action in depressed and treatment-resistant
depressed patients within hours. At the same time, ketamine elicits a unique form of …

Background Autism spectrum disorder (ASD) is a neurodevelopmental condition, which is
characterized by clinical heterogeneity and high heritability. Core symptoms of ASD include …

To perform computations with the efficiency necessary for animal survival, neocortical
microcircuits must be capable of reconfiguring in response to experience, while carefully …

Abstract Background Phelan–McDermid syndrome (PMS) is a neurodevelopmental disorder
characterized by developmental delay, intellectual disability, and autistic-like behaviors and …

Autism spectrum disorders (ASD) is a heterogeneous group of neurodevelopmental
disorders characterized by synaptic dysfunction and defects in dendritic spine morphology …

Recent advances in genomics have revealed a wide spectrum of genetic variants
associated with neurodevelopmental disorders at an unprecedented scale. An increasing …

Sensory atypicalities in autism spectrum disorder (ASD) are thought to arise at least partly
from differences in γ-aminobutyric acid (GABA) receptor function. However, the evidence to …

The neurobiological understanding of obsessive–compulsive disorder (OCD) includes
dysregulated frontostriatal circuitry and altered monoamine transmission. Repetitive …