First contact: the role of respiratory cilia in host-pathogen interactions in the airways
LE Kuek, RJ Lee - … Journal of Physiology-Lung Cellular and …, 2020 - journals.physiology.org
Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …
[HTML][HTML] Epithelial barrier dysfunction in chronic respiratory diseases
FM Carlier, C de Fays, C Pilette - Frontiers in physiology, 2021 - frontiersin.org
Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …
module that ensures first-line defense against external toxics, irritants, antigens, and …
[HTML][HTML] SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance
R Robinot, M Hubert, GD de Melo, F Lazarini… - Nature …, 2021 - nature.com
Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define
the parameters controlling the severity of COVID-19. Here we examine the functional and …
the parameters controlling the severity of COVID-19. Here we examine the functional and …
[HTML][HTML] Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells
N Zhu, W Wang, Z Liu, C Liang, W Wang, F Ye… - Nature …, 2020 - nature.com
Abstract SARS-CoV-2, a β-coronavirus, has rapidly spread across the world, highlighting its
high transmissibility, but the underlying morphogenesis and pathogenesis remain poorly …
high transmissibility, but the underlying morphogenesis and pathogenesis remain poorly …
Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models
Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide,
is highly heritable. While COPD is clinically defined by applying thresholds to summary …
is highly heritable. While COPD is clinically defined by applying thresholds to summary …
[HTML][HTML] Magnetic cilia carpets with programmable metachronal waves
Metachronal waves commonly exist in natural cilia carpets. These emergent phenomena,
which originate from phase differences between neighbouring self-beating cilia, are …
which originate from phase differences between neighbouring self-beating cilia, are …
Diagnosis, monitoring, and treatment of primary ciliary dyskinesia: PCD foundation consensus recommendations based on state of the art review
AJ Shapiro, MA Zariwala, T Ferkol… - Pediatric …, 2016 - Wiley Online Library
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous, rare lung disease resulting
in chronic oto‐sino‐pulmonary disease in both children and adults. Many physicians …
in chronic oto‐sino‐pulmonary disease in both children and adults. Many physicians …
Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …
membranes and associated proteins are linked to the thermodynamics and kinetics of …
[HTML][HTML] Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank data
Background The severity of coronavirus disease 2019 (COVID-19) caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly heterogeneous. Studies …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly heterogeneous. Studies …
Sperm ion channels and transporters in male fertility and infertility
Mammalian sperm cells must respond to cues originating from along the female
reproductive tract and from the layers of the egg in order to complete their fertilization …
reproductive tract and from the layers of the egg in order to complete their fertilization …