Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance
Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
The molecular basis of heterochromatin assembly and epigenetic inheritance
SIS Grewal - Molecular cell, 2023 - cell.com
Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …
silencing of repetitive DNA elements. Histone modifications are essential for the …
[HTML][HTML] Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
A general approach for heritably altering gene expression has the potential to enable many
discovery and therapeutic efforts. Here, we present CRISPRoff—a programmable epigenetic …
discovery and therapeutic efforts. Here, we present CRISPRoff—a programmable epigenetic …
Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation
MAJ Morgan, A Shilatifard - Nature genetics, 2020 - nature.com
Histone-modifying enzymes are implicated in the control of diverse DNA-templated
processes including gene expression. Here, we outline historical and current thinking …
processes including gene expression. Here, we outline historical and current thinking …
Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma
The histone methyltransferase activity of PRC2 is central to the formation of H3K27me3-
decorated facultative heterochromatin and gene silencing. In addition, PRC2 has been …
decorated facultative heterochromatin and gene silencing. In addition, PRC2 has been …
[HTML][HTML] Regulatory mechanisms governing chromatin organization and function
R Villaseñor, T Baubec - Current Opinion in Cell Biology, 2021 - Elsevier
Nucleosomes, the basic structures used to package genetic information into chromatin, are
subject to a diverse array of chemical modifications. A large number of these marks serve as …
subject to a diverse array of chemical modifications. A large number of these marks serve as …
Drug design targeting active posttranslational modification protein isoforms
Modern drug design aims to discover novel lead compounds with attractable chemical
profiles to enable further exploration of the intersection of chemical space and biological …
profiles to enable further exploration of the intersection of chemical space and biological …
Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3
Nuclear RNAi provides a highly tractable system to study RNA-mediated chromatin changes
and epigenetic inheritance. Recent studies have indicated that the regulation and function of …
and epigenetic inheritance. Recent studies have indicated that the regulation and function of …
Approaching the catalytic mechanism of protein lysine methyltransferases by biochemical and simulation techniques
Protein lysine methyltransferases (PKMTs) transfer up to three methyl groups to the side
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …
chains of lysine residues in proteins and fulfill important regulatory functions by controlling …
Uncoupling the distinct functions of HP1 proteins during heterochromatin establishment and maintenance
M Seman, A Levashkevich, A Larkin, F Huang… - Cell reports, 2023 - cell.com
Summary H3K9 methylation (H3K9me) marks transcriptionally silent genomic regions called
heterochromatin. HP1 proteins are required to establish and maintain heterochromatin. HP1 …
heterochromatin. HP1 proteins are required to establish and maintain heterochromatin. HP1 …