Cutting-edge lipidomic profiling measures hundreds or even thousands of lipids in plasma
and is increasingly used to investigate mechanisms of cardiovascular disease (CVD). In this …

Cardiovascular disease is the leading global health concern and responsible for more
deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory …

Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …

Ferroptosis—an iron-dependent, non-apoptotic cell death process—is involved in various
degenerative diseases and represents a targetable susceptibility in certain cancers. The …

Objective Tryptophan can be catabolised to various metabolites through host kynurenine
and microbial indole pathways. We aimed to examine relationships of host and microbial …

Aims To investigate whether metabolic signature composed of multiple plasma metabolites
can be used to characterize adherence and metabolic response to the Mediterranean diet …

Experimental studies reported biochemical actions underpinning aging processes and
mortality, but the relevant metabolic alterations in humans are not well understood. Here we …

Endothelial nitric oxide synthase (eNOS) is protective against kidney injury, but the
molecular mechanisms of this protection are poorly understood,. Nitric oxide-based cellular …

Aims/hypothesis Plant-based diets, especially when rich in healthy plant foods, have been
associated with a lower risk of type 2 diabetes. However, whether plasma metabolite profiles …

Background: Whereas regular exercise is associated with lower risk of cardiovascular
disease and mortality, mechanisms of exercise-mediated health benefits remain less clear …