Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …

Abstract Calcium (Ca 2+) is a ubiquitous second messenger that regulates various activities
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …

Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause
of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there …

Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Abstract Calcium (Ca 2+) is an universal second messenger that regulates the most
important activities of all eukaryotic cells. It is of critical importance to neurons as it …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

Presenilins were first discovered as sites of missense mutations responsible for early-onset
Alzheimer disease (AD). The encoded multipass membrane proteins were subsequently …

Perturbed neuronal Ca 2+ homeostasis is implicated in age-related cognitive impairment
and Alzheimer's disease (AD). With advancing age, neurons encounter increased oxidative …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …