The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …

Pseudomonas aeruginosa is a Gram-negative bacterial pathogen that is a common cause of
nosocomial infections, particularly pneumonia, infection in immunocompromised hosts, and …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Early recognition and treatment of sepsis are linked to improved patient outcomes. Machine
learning-based early warning systems may reduce the time to recognition, but few systems …

Background Intravenous fluids are recommended for the treatment of patients who are in
septic shock, but higher fluid volumes have been associated with harm in patients who are …

Acute mesenteric ischemia (AMI) is a group of diseases characterized by an interruption of
the blood supply to varying portions of the intestine, leading to ischemia and secondary …

This guideline is based on the above strategic priorities, and is intended for clinicians
involved in the care of patients with suspected or confirmed COVID-19. It is not meant to …

Abstract These European Resuscitation Council (ERC) Cardiac Arrest in Special
Circumstances guidelines are based on the 2020 International Consensus on …

The guidance in this document is based on the above strategic priorities, and is intended for
clinicians involved in the care of patients with suspected or confirmed COVID-19. It is not …

Sepsis is expected to have a substantial impact on public health and cost as its prevalence
increases. Factors contributing to increased prevalence include a progressively aging …