The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

Historically, drug research targeted to pain treatment has focused on trying to prevent the
propagation of action potentials in the periphery from reaching the brain rather than …

Few conventional cytotoxic anticancer therapeutics induce immunogenic cell death (ICD).
This means that they induce tumor cells to undergo apoptosis while eliciting the emission of …

He's an alpha wolf and a beta boyfriend. She's dated every monster in New York City. It's
time for their Meat-Cute. Michael Andrews, a Canadian living in New York, is learning to live …

An urgent need exists to improve the outcomes of patients with muscle-invasive bladder
cancer (MIBC), and especially of those with metastatic disease. Treatments that enhance …

Neurogenic detrusor overactivity (NDO) can result in lower and upper urinary tract
complications and eventually even in end-stage kidney failure. Since the driving force of this …

Rationale. Overactive bladder (OAB) is a common, distressing condition that worsens with
age and impacts quality of life significantly. As a results of its clinical symptoms, patients …

AIMS: A broad spectrum of synthetic agents is available for the treatment of overactive
bladder. Anti-cholinergic drugs show a poor compliance due to side effects. There is an …

The effects of the Kv7 channel modulators retigabine (opener) and XE991 (blocker) on rat
bladder function were investigated ex vivo and in vivo to assess the potential of Kv7 openers …

The initial concept for Mechanobiology Handbook spawned from the insightful vision of a
CRC Press editor, Michael Slaughter, who found potential in the growth of this field and took …