Nearly 30 hereditary disorders in humans result from an increase in the number of copies of
simple repeats in genomic DNA. These DNA repeats seem to be predisposed to such …

Accurate and complete replication of the genome in every cell division is a prerequisite of
genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely …

The history of investigations on non-B DNA conformations as related to genetic diseases
dates back to the mid-1960s. Studies with high molecular weight DNA polymers of defined …

Repetitive genomic sequences can adopt a number of alternative DNA structures that differ
from the canonical B-form duplex (ie non-B DNA). These non-B DNA-forming sequences …

Expansions of simple DNA repeats are responsible for more than two dozen hereditary
disorders in humans, including fragile X syndrome, myotonic dystrophy, Huntington's …

Non-canonical secondary structures (NCSs) are alternative nucleic acid structures that differ
from the canonical B-DNA conformation. NCSs often occur in repetitive DNA sequences and …

Friedreich's ataxia (GAA) n repeats of various lengths were cloned into a Saccharymyces
cerevisiae plasmid, and their effects on DNA replication were analyzed using two …

Substantial progress has been realized in the past several years in our understanding of the
molecular mechanisms responsible for the expansions and deletions (genetic instabilities) …

CANVAS is a recently characterized repeat expansion disease, most commonly caused by
homozygous expansions of an intronic (A2G3) n repeat in the RFC1 gene. There are a …

Short tandem repeats (STRs) are a class of repetitive elements, composed of tandem arrays
of 1–6 base pair sequence motifs, that comprise a substantial fraction of the human genome …