Preclinical animal anxiety research–flaws and prejudices

A Ennaceur, PL Chazot - Pharmacology research & …, 2016 - Wiley Online Library
The current tests of anxiety in mice and rats used in preclinical research include the elevated
plus‐maze (EPM) or zero‐maze (EZM), the light/dark box (LDB), and the open‐field (OF) …

Investigating the effect of physiological need states on palatability and motivation using microstructural analysis of licking

F Naneix, KZ Peters, JE McCutcheon - Neuroscience, 2020 - Elsevier
The study of consummatory responses during food intake represents a unique opportunity to
investigate the physiological, psychological and neurobiological processes that control …

Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades

D Wahlsten, A Bachmanov, DA Finn… - Proceedings of the …, 2006 - National Acad Sciences
If we conduct the same experiment in two laboratories or repeat a classical study many
years later, will we obtain the same results? Recent research with mice in neural and …

Breadth of tuning in taste afferent neurons varies with stimulus strength

A Wu, G Dvoryanchikov, E Pereira, N Chaudhari… - Nature …, 2015 - nature.com
Gustatory stimuli are detected by taste buds and transmitted to the hindbrain via sensory
afferent neurons. Whether each taste quality (sweet, bitter and so on) is encoded by …

Neural landscape is associated with functional outcomes in irradiated patients with oropharyngeal squamous cell carcinoma

S Islam, FO Gleber-Netto, CF Mulcahy… - Science translational …, 2024 - science.org
The incidence of human papilloma virus–mediated oropharyngeal squamous cell carcinoma
(OPSCC) has increased over the past 40 years, particularly among young individuals with a …

[HTML][HTML] Modulation of taste responsiveness by the satiation hormone peptide YY

MS La Sala, MD Hurtado, AR Brown… - The FASEB …, 2013 - ncbi.nlm.nih.gov
It has been hypothesized that the peripheral taste system may be modulated in the context of
an animal's metabolic state. One purported mechanism for this phenomenon is that …

Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal

Y Treesukosol, AC Spector - American Journal of …, 2012 - journals.physiology.org
Evidence in the literature supports the hypothesis that the T1R2+ 3 heterodimer binds to
compounds that humans describe as sweet. Here, we assessed the necessity of the T1R2 …

An analysis of licking microstructure in three strains of mice

AW Johnson, A Sherwood, DR Smith, M Wosiski-Kuhn… - Appetite, 2010 - Elsevier
Mouse models of feeding provide a useful tool for elucidating the molecular pathways of
energy regulation. The majority of studies in mice have been limited to intake analyses …

C57BL/6J and DBA/2J mice vary in lick rate and ingestive microstructure

JD Boughter Jr, JP Baird, J Bryant… - Genes, Brain and …, 2007 - Wiley Online Library
Fluid licking in mice is an example of a rhythmic behavior thought to be under the control of
a central pattern generator. Inbred strains of mice have been shown to differ in mean or …

Ethanol drinking microstructure of a high drinking in the dark selected mouse line

AM Barkley‐Levenson… - Alcoholism: Clinical and …, 2012 - Wiley Online Library
Background The High Drinking in the Dark (HDID) selected mouse line was bred for high
blood ethanol (E t OH) concentration (BEC) following the limited access drinking in the dark …