Strategies toward rheumatoid arthritis therapy; the old and the new

M Abbasi, MJ Mousavi, S Jamalzehi… - Journal of cellular …, 2019 - Wiley Online Library
Currently, medications used to treat rheumatoid arthritis (RA) are glucocorticoids (GCs) and
nonsteroidal anti‐inflammatory drugs (NSAIDs), predominantly used for controlling the pain …

Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review

J Karami, S Aslani, A Jamshidi, M Garshasbi… - Gene, 2019 - Elsevier
Three important factors, including genetics, environment factors and autoimmunity play a
role in the pathogenesis of rheumatoid arthritis (RA). The heritability of RA has been …

Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis

K Furuta, Q Guo, KD Pavelko, JH Lee… - The Journal of …, 2021 - Am Soc Clin Investig
Monocyte homing to the liver and adhesion to the liver sinusoidal endothelial cells (LSECs)
are key elements in nonalcoholic steatohepatitis (NASH) pathogenesis. We reported …

Cardiometabolic comorbidities in RA and PsA: lessons learned and future directions

LD Ferguson, S Siebert, IB McInnes… - Nature Reviews …, 2019 - nature.com
Cardiometabolic comorbidities present a considerable burden for patients with rheumatoid
arthritis (RA) or psoriatic arthritis (PsA). Both RA and PsA are associated with an increased …

Extra-articular rheumatoid arthritis

E Marcucci, E Bartoloni, A Alunno, MC Leone, G Cafaro… - 2018 - reumatismo.org
Rheumatoid arthritis (RA) is a chronic inflammatory disease that mainly affects the joints,
though a consistent proportion of patients may also display extra articular manifestations …

Consensus recommendations on managing the selected comorbidities including cardiovascular disease, osteoporosis, and interstitial lung disease in rheumatoid …

KH Yu, HH Chen, TT Cheng, YJ Jan, MY Weng, YJ Lin… - Medicine, 2022 - journals.lww.com
Background: Rheumatoid arthritis (RA)-related comorbidities, including cardiovascular
disease (CVD), osteoporosis (OP), and interstitial lung disease (ILD), are sub-optimally …

Autoimmune rheumatic diseases and vascular function: the concept of autoimmune atherosclerosis

AM Hedar, MH Stradner, A Roessler… - Journal of clinical …, 2021 - mdpi.com
Autoimmune rheumatic diseases (AIRDs) with unknown etiology are increasing in incidence
and prevalence. Up to 5% of the population is affected. AIRDs include rheumatoid arthritis …

Lower serum levels of Meteorin-like/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and …

M Dadmanesh, H Aghajani, R Fadaei, K Ghorban - PloS one, 2018 - journals.plos.org
Meteorin-like (Metrnl) is a newly discovered adipokine with favorable effect on insulin
sensitivity. Previous studies have reported lower levels of Metrnl in obese patients. However …

Exploring the therapeutic promise of targeting HMGB1 in rheumatoid arthritis

I Kaur, T Behl, S Bungau, A Kumar, V Mehta, D Setia… - Life Sciences, 2020 - Elsevier
High mobility group box-1 (HMGB1) protein is a diverse, single polypeptide moiety, present
in mammalian eukaryotic cells. In response to stimuli, this nuclear protein is actively …

Decreased serum levels of CTRP12/adipolin in patients with coronary artery disease in relation to inflammatory cytokines and insulin resistance

R Fadaei, N Moradi, T Kazemi, E Chamani, N Azdaki… - Cytokine, 2019 - Elsevier
Coronary artery disease (CAD) is the leading cause of death worldwide. Atherosclerosis as
the main underlying mechanism of CAD is associated with inflammation and adipose tissue …