Glycerolipid synthesis and lipid droplet formation in the endoplasmic reticulum
RV Farese, TC Walther - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
More than 60 years ago, Eugene Kennedy and coworkers elucidated the endoplasmic
reticulum (ER)-based pathways of glycerolipid synthesis, including the synthesis of …
reticulum (ER)-based pathways of glycerolipid synthesis, including the synthesis of …
[HTML][HTML] Cellular uptake, metabolism and sensing of long-chain fatty acids
Q He, Y Chen, Z Wang, H He, P Yu - Frontiers in Bioscience …, 2023 - imrpress.com
Fatty acids (FAs) are critical nutrients that regulate an organism's health and development in
mammal. Long-chain fatty acids (LCFAs) can be divided into saturated and unsaturated fatty …
mammal. Long-chain fatty acids (LCFAs) can be divided into saturated and unsaturated fatty …
[HTML][HTML] Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C
Non-specific phospholipase C (NPC) hydrolyzes major membrane phospholipids to release
diacylglycerol (DAG), a potent lipid-derived messenger regulating cell functions. Despite …
diacylglycerol (DAG), a potent lipid-derived messenger regulating cell functions. Despite …
Coupling lipid synthesis with nuclear envelope remodeling
SR Barger, L Penfield, S Bahmanyar - Trends in biochemical sciences, 2022 - cell.com
The nuclear envelope (NE) is a protective barrier to the genome, yet its membranes undergo
highly dynamic remodeling processes that are necessary for cell growth and maintenance …
highly dynamic remodeling processes that are necessary for cell growth and maintenance …
Phosphatidylserine enrichment in the nuclear membrane regulates key enzymes of phosphatidylcholine synthesis
Y Niu, JG Pemberton, YJ Kim, T Balla - The EMBO Journal, 2024 - embopress.org
Phosphatidylserine (PS) is an important anionic phospholipid that is synthesized within the
endoplasmic reticulum (ER). While PS shows the highest enrichment and serves important …
endoplasmic reticulum (ER). While PS shows the highest enrichment and serves important …
Structure and regulation of human phospholipase D
Mammalian phospholipase D (PLD) generates phosphatidic acid, a dynamic lipid secondary
messenger involved with a broad spectrum of cellular functions including but not limited to …
messenger involved with a broad spectrum of cellular functions including but not limited to …
[HTML][HTML] Phosphatidate phosphatase Pah1 contains a novel RP domain that regulates its phosphorylation and function in yeast lipid synthesis
The Saccharomyces cerevisiae PAH1-encoded phosphatidate (PA) phosphatase, which
catalyzes the Mg 2+-dependent dephosphorylation of PA to produce diacylglycerol, is one of …
catalyzes the Mg 2+-dependent dephosphorylation of PA to produce diacylglycerol, is one of …
[HTML][HTML] Current advancements and future perspectives of long noncoding RNAs in lipid metabolism and signaling
Background The investigation of lncRNAs has provided a novel perspective for elucidating
mechanisms underlying diverse physiological and pathological processes. Compelling …
mechanisms underlying diverse physiological and pathological processes. Compelling …
Structure and mechanism of the human CTDNEP1–NEP1R1 membrane protein phosphatase complex necessary to maintain ER membrane morphology
S Gao, JW Carrasquillo Rodríguez… - Proceedings of the …, 2024 - National Acad Sciences
C-terminal Domain Nuclear Envelope Phosphatase 1 (CTDNEP1) is a noncanonical protein
serine/threonine phosphatase that has a conserved role in regulating ER membrane …
serine/threonine phosphatase that has a conserved role in regulating ER membrane …
[HTML][HTML] Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents
Pathogenic fungi exhibit a heavy burden on medical care and new therapies are needed.
Here, we develop the fungal specific enzyme sterylglucosidase 1 (Sgl1) as a therapeutic …
Here, we develop the fungal specific enzyme sterylglucosidase 1 (Sgl1) as a therapeutic …