Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints
them with a variety of inflammatory processes. For example, platelets can act as circulating …

HIV-1 envelope glycoprotein [Env; trimeric (gp160) 3 cleaved to (gp120/gp41) 3] attaches
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

The first step of the human immunodeficiency virus (HIV) replication cycle—binding and
entry into the host cell—plays a major role in determining viral tropism and the ability of HIV …

Spike (S) proteins of coronaviruses, including the coronavirus that causes severe acute
respiratory syndrome (SARS), associate with cellular receptors to mediate infection of their …

Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary
immune responses. DCs capture and transfer information from the outside world to the cells …

Transition metal‐catalysed processes have been widely used for the functionalization of
inert C− H bonds. Strategies for the functionalization of the benzylic C− H position having a …

The attraction of leukocytes to tissues is essential for inflammation and the host response to
infection. The process is controlled by chemokines, which are chemotactic cytokines. This …

Rare individuals have been multiply exposed to HIV-1 but remain uninfected. The CD4+ T-
cells of two of these individuals, designated EU2 and EU3, are highly resistant in vitro to the …

HIV-1 and related viruses require co-receptors, in addition to CD4, to infect target cells. The
chemokine receptor CCR-5 (ref. 1) was recently demonstrated to be a co-receptor for …