Cloned probes specific for unique genes have proven to be powerful tools in defining the
nature of genetic diseases such as the thalassaemias1 and growth hormone deficiencies2 …

We report the cloning of five overlapping cDNAs bearing sequences specific for the human
proα1 (I) collagen chain. Poly-A RNA enriched for collagen sequences was purified from …

Extracellular matrices are organized networks of diverse macromolecules, secreted and
deposited in the vicinity of cells. They not only play structural roles but are also involved in …

We have determined the size and sequence of 8 exons in the gene that specifies chick type I
cr2 collagen. These 8 exons represent three different segments of the gene, but all encode …

We studied the methylation pattern of the a2 (type I) collagen gene in DNA from five cell
types with varying rates of type I collagen synthesis: chick embryo fibroblast (CEF), CEF …

The complete nucleotide sequence of the gene and mRNA coding for the constant (C)
region of the secreted form of the BALB/c mouse IgA immunoglobulin alpha heavy (H) chain …

In considering the origin and evolution of proteins, the possibility that proteins evolved from
exons coding for specific structure-function modules is attractive for its economy and …

Poly (A)-RNA enriched for type I procollagen sequences was isolated from normal human
fibroblasts and used as template to synthesize double-stranded cDNA with avian …

Materials and Methods Isolation of Bovine DM. Adult bovine eyes were obtained from Pel
Freeze Biologicals (Rogers, AK) and were stored on 1 Abbreviations: BM, basement …

A transcriptional enhancer has been identified in the first intron of the mouse alpha 2 (type I)
collagen gene in a region between+ 418 and+ 1524 base pairs from the transcriptional start …